EDISCIENCES

ABSTRACT

Abstract Introduction The problem of nausea and vomiting from chemotherapy is not fully solved to date, mainly due to poor adherence to guidelines, but also because the guidelines are based on data from randomized control- led studies that do not always adequately represent patients with signi cant comorbidities and are often not adapted for individual patients. Methods A multidisciplinary panel of experts met to discuss a patient-orien- ted approach to antiemetic treatment in special oncology adult po- pulations, including geriatric patients, those with a high burden of comorbidities and those receiving polypharmacy. The panel inclu- ded oncologists, geriatric oncologists, and cardiologists. We identi- ed critical situations in clinical practice that are not well addressed by the guidelines. A multidisciplinary discussion highlighted unmet needs and suggested solutions. Results We have analysed particular clinical situations in the context of a multidisciplinary panel of experts to search for antiemetic solutions that are based as much as possible on personalized medicine. We have addressed older patients, patients with cardiovascular condi- tions and patients receiving polytherapy. These situations are com- mon among oncology patients. Conclusions Recent advances in antiemetic research lead to less complicated prophylactic regimens, as novel agents or formulations are introdu- ced with better tolerability and safety pro les while requiring fewer doses.