Bone preservation in the early breast cancer
S. Bordonaro, P. Tralongo
Vol.7 (2022), issue 1, pag. 125 - 138
| Received | 2/08/2021 |
| Accepted | 2/01/2022 |
| Published | 24/03/2022 |
| Review by | Double-blind |
| DOI | https://doi.org/10.48253/AGO26 |
ABSTRACT
Breast cancer, especially in its early stages, and the treatments used for its cure represent a predisposing factor for osteoporosis, particularly after menopause. The long-term effects of the thera- pies, which have allowed a decrease in cancer-speci c mortality, represent a priority element for the preservation of bone health in long-term survivors with breast cancer. Osteoporosis and survival management require a multidisciplinary approach that is based on the assessment of risk factors for bone loss, optimization of bone health through lifestyle-related approaches and pharmacological interventions based on precise algorithms. This short review will present a background on bone physiology and pathophysiology, the effects on bone of cancer-speci c treatments and a brief evi- dence-based analysis for the management of treatments aimed at preserving bone health.