IL TRATTAMENTO DEL CARCINOMA SQUAMOSO DELLA CUTE C. Trojaniello, P.A. Ascierto Vol.3 (2018), issue 3, pag. 6-16
Accepted after revision
Advanced cutaneous squamous cell carcinoma (cSCC) is the skin cancer with the highest mortality rate after melanoma. When diagnosed at an early stage, it has a favorable progno- sis, while it becomes dangerous in case of advanced stage with a strong impact on the quality of life, sometimes causing permanent deformations. In some cases, cSCC gives metastases to the lymph nodes and visceral organs, becoming potentially fatal. Advanced cSCC inclu- des both locally advanced not surgically resectable and metastatic disease.
If diagnosed on time, surgery and radiotherapy can be curative. However in those cases in which the tumor is not surgically resectable or in case of metastatic disease, currently there are no therapies approved by the EMA or FDA. Surgery remains therefore the first choice treatment for these tumors, while radiotherapy and systemic chemotherapy are used in case of lymph nodes or visceral involvement.
At moment are ongoing several studies with the of immunotherapy. Some of these studies showed interesting signal of efficacy in cSCC, with long-term responses and limited toxicity.