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ABSTRACT
Frailty is a still-evolving concept of a complex phenomenon. There are
several algorithms and strategies for assessing frailty syndrome, but
currently, no universally accepted definition or measurement protocol
has been determined. Consequently, the biological cause(s) of frailty
are also poorly defined. Much circumstantial experimental data point
to the dysregulation of several key physiological systems, including the neuroendocrine, musculoskeletal, metabolic and immune/inflammatory systems, resulting from alterations in functional reserves. Social
determinants of health are major factors responsible for population’s
health and health inequalities.
