TRATTAMENTO DEL GLIOBLASTOMA MULTIFORME NELL'ANZIANO M. Picciotto, A. Russo, V. Guarini, A. Santacaterina, F. Tindara Vol.2 (2017), issue 4, pag.14-19
Accepted for pubblication
Glioblastoma multiforme (GBM) is the most frequent primitive brain tumor of the adult, which is commonly associated with a dismal prognosis. Incidence of GBM is growing, with a higher incidence among elderly. However, ≥65 years old patients are usually excluded from the vast majority of clinical trials with chemotherapy and/or radiotherapy, because of toxicity concerns. Therefore, despite major breakthroughs in the last few decades in the treatment of GBM, the optimal treatment of elderly patients is still matter of debate and most of them
are usually undertreated. The aim of this review is to provide a comprehensive overview of the latest evidence of treatment options in elderly GBM.