EDISCIENCES

ABSTRACT

Background: Pediatric cancer remains a significant public health concern in low- and middle-income countries (LMICs), where survival rates are substantially lower than in high-income (HICs) settings. Children undergoing cancer treatment experience considerable physical and psychosocial challenges that negatively impact quality of life (QoL). Evidence supporting integrated rehabilitation interventions, such as combined physiotherapy and music therapy, is limited, particularly in LMIC contexts. Objective: This study aims to evaluate the feasibility and preliminary effectiveness of a combined physiotherapy and music therapy intervention for hospitalized children with cancer in Gauteng, South Africa, and to develop contextually relevant, evidence-based rehabilitation guidelines. Methods: A three-phase mixed-methods design will be employed: (1) a scoping review of existing literature; (2) a feasibility trial conducted in a pediatric oncology ward; and (3) guideline development using a structured stakeholder consensus approach. Significance: The findings will contribute to the development of multidisciplinary, culturally appropriate rehabilitation strategies to improve functional outcomes and QoL among children with cancer in resource- constrained settings.