R. Labianca, G. Piacentini, C. Sansi, A. Labianca, S. Mosconi, E. Arnoldi
Vol.3 (2018), issue 2, pag.11-16

Received 30/03/2018
Accepted for pubblication 26/04/2018
Published May 2018
Review by Single-blind
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Incidence of colorectal cancer increases with advancing age and median age at diagnosis is 72 years. e bene t of adjuvant chemotherapy, with uo-rouracil or capecitabine with or without oxaliplatin, has been established in many clinical trials. The impact of adjuvant chemotherapy on survival in older adults is not well de ned, given that only a small percentage (< 10 %) of elderly patients (> 70 years) is included in these studies. Data from pooled-analysis support disease-free survival and overall survival benefit after fuorouracil-based adjuvant therapy in stage III elderly and fit patients. Instead, there is disagreement regarding benefit of adding oxalplatin in elderly patients. Disease-free survival bene t has been identi ed in some elderly patients, however it is still not clear how to define this subset of patients. The safety profile of doublet chemotherapy is similar when comparing age < 70 and >= 70 sub-groups. Potential benefit from adjuvant chemotherapy in older adults must be weighTed against the risks attributable to increased toxicity, reduced organ function and limited social support. Comorbidities, as competing causes of death, play an essential role in determinig the survival of elderly patients and can diminish or negate the benefit of adjuvant chemotherapy. Comprehensive geriatric assessment is recommended to de ne the presence or absence of frailty.