CHEMIOTERAPIA DEL CARCINOMA MAMMARIO AVANZATO.
QUALE FARMACO? QUALE MODALITÁ?

I. Puliafito, A. Prestifilippo, G. Blanco, D. Sciacca, D. Giuffrida
Vol.2 (2017), issue 4, pag.20-23

Received 13/11/2017
Accepted for pubblication 29/11/2017
Published Dec. 2017
Review by Single-blind
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This paper evaluates the role of chemotherapy in elderly patients with advanced breast cancer. Clinical trials demonstrate that risk of mortality increases in patients with age> 70 at start of therapy but age is not the only prognostic factor causing a short survival; negative HER2 or hormone receptor status, multiple metastatic sites, high grade and comorbidities influence prognosis. Several agents are used as monochemotherapy with a good response rate and poliche- motherapy is a valid option in selected patients. Metronomic chemotherapy represents a valid option with a good efficacy and tolerability. Clinical trials are needed to confirm the role of chemotherapy in elderly women with metastatic breast cancer.