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Submission To Be Reviewed

Title:  Treatment of squamous carcinoma

Journal Section


Advanced cutaneous squamous cell carcinoma (cSCC) is the skin cancer with the highest mortality rate after melanoma. When diagnosed at an early stage, it has a favorable prognosis, while it becomes dangerous in case of advanced stage with a strong impact on the quality of life, sometimes causing permanent deformations. In some cases, cSCC gives metastases to the lymph nodes and visceral organs, becoming potentially fatal. Advanced cSCC includes both locally advanced not surgically resectable and metastatic disease.

If diagnosed on time, surgery and radiotherapy can be curative. Howeverin those cases in which the tumor is not surgicallyresectable or in case of metastatic disease, currently there are no therapies approved by the EMA or FDA.Surgery remains therefore the first choice treatment for these tumors, while radiotherapy and systemic chemotherapy are used in case of lymph nodes or visceral involvement.

At moment are ongoing several studies with the of immunotherapy. Some of these studiesshowed interesting signal of efficacy in cSCC, with long-term responses and limited toxicity.


Key words: 

squamous cell carcinoma, treatment, immunotherapy, toxicity, anti PD-1

Review Schedule

Editor's request 18-09-2018

Your Response 

Review Submitted 

Review Due 


1) Does this paper present new ideas or results that have not been previously published? 2) Is the research presented in the article new or build upon existing research? 3) Does the article point out differences from related research?
Does the article make a considerable contribution to the oncology field?
1) Does the title clearly express the content of the article? Is 2) Is the abstract sufficiently informative and provides a good perspective on the final message of the aricle?
1) Are the methods used clearly explained? 2) Are they a recognized approach? 3) Are the data and statistics used reliable?
1) Are they clearly presented? 2) Do they avoid misinterpretation? 3) Do they sufficiently avoid assumptions and speculations?
1) Do they reflect the latest research in the area? 2) Are they correctly indicated in article? 3) Are they correctly formatted according to the author guidelines?
1) Are the tables correctly name and numbered? 2) Are the data presented in the table correctly interpreted in the article?
1) Are the figures correctly named and numbered? 2) Do they properly illustrate what is discussed in the article? 3) Are they correctly interpreted in the article?
1) Is the article clearly written?
1) Does the article fit the guidelines for the section as outlined in the instructions to authors?
Please rate the article in priority for publication based on the interest to our readership and contribution to the oncology field. (5) Being of hieghest priority and (1) being the lowest.