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Submission To Be Reviewed

Title: Il trattamento del carcinoma mammario "triple-negative" nella donna anziana

Journal Section


Although breast cancer is generally considered to be indolent in the elderly, there is certain variability in its characteristics and clinical outcomes in the oldest population. Indeed, a substantial proportion of older women have a diagnosis of triple-negative breast cancer (TNBC), a subtype with usually poor prognosis.

TNBC in the elderly represents a substantial treatment challenge: geriatric assessment and life expectancy evaluation are mandatory. Local treatments, such as surgery and radiation, and adjuvant chemotherapy play a central role in early stage TNBC whereas chemotherapy remains the cornerstone of the systemic treatment of metastatic TNBC. 

However, few randomized controlled trials have been conducted to evaluate the effectiveness of breast cancer treatments on women aged 70 or older. Hence, the less aggressive treatment strategies, usually chosen to respect patients’ frailty and vulnerability, are mostly empirical and not evidence-based.

As a consequence, the impact of potential undertreatment on cancer recurrence and overall survival is not known. The identification of new strategies is therefore urgently needed to guarantee the best therapeutic chances to elderly patients with TNBC without exposing them to unacceptable and dangerous toxicities.


Key words: 

triple-negative breast cancer, elderly, treatment, geriatric, chemotherapy, toxicity



Review Schedule

Editor's request 26-03-2018

Your Response 

Review Submitted 

Review Due 


1) Does this paper present new ideas or results that have not been previously published? 2) Is the research presented in the article new or build upon existing research? 3) Does the article point out differences from related research?
Does the article make a considerable contribution to the oncology field?
1) Does the title clearly express the content of the article? Is 2) Is the abstract sufficiently informative and provides a good perspective on the final message of the aricle?
1) Are the methods used clearly explained? 2) Are they a recognized approach? 3) Are the data and statistics used reliable?
1) Are they clearly presented? 2) Do they avoid misinterpretation? 3) Do they sufficiently avoid assumptions and speculations?
1) Do they reflect the latest research in the area? 2) Are they correctly indicated in article? 3) Are they correctly formatted according to the author guidelines?
1) Are the tables correctly name and numbered? 2) Are the data presented in the table correctly interpreted in the article?
1) Are the figures correctly named and numbered? 2) Do they properly illustrate what is discussed in the article? 3) Are they correctly interpreted in the article?
1) Is the article clearly written?
1) Does the article fit the guidelines for the section as outlined in the instructions to authors?
Please rate the article in priority for publication based on the interest to our readership and contribution to the oncology field. (5) Being of hieghest priority and (1) being the lowest.